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It is likely that SufA1 serves as a back-up carrier for classic 2Fe-2S (Figure 4A), when other classic 2Fe-2S carriers are insufficient, e.g., under stress conditions

doi: 10.1016/j.jns.2017.01.060 132 ZhouYCuellar-PartidaGSimpson YapSLinXClaflinSBurdonKet al

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It prevents erastin-induced ferroptosis by inhibiting GSH and GPX4 degradation, reducing lipid peroxidation, and activating the Nrf2 pathway to mitigate oxidative damage, showing promise in treating AD and PD (Li Y