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Glucose is consumed excessively in many developed countries and while it is essential for cellular respiration, it possesses absorption-enhancing properties that elevates intestinal permeability (Lerner and Matthias 2015a)

Because it lacks long-term human clinical trials, the full long-term side effect profile is unknown

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Researchers studying NAD+ biology or methyl-donor pools should evaluate primary sources directly and note that NNMT inhibition has distinct mechanistic implications compared to direct NAD+ precursor supplementation with molecules like NMN or NAD+ itself