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Name: glutathione in dermatology as a skin‐lightening agent and melasma: a systematic review - Sarkar - 2025 - International Journal of Glutathione for skin lightening: a
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Diabetologia 60:15661576 Wang GS, Hoyte C (2019) Review of Biguanide (metformin) toxicity

doi: 10.1016/j.nut.2004.03.022 12

However, scientific evidence for site-specific enhancement is limited

Two studies have reported the involvement of the lncRNA MEG3 in the development of GH-secreting pituitary adenomas (70, 71)

Regarding safety, large cohort studies have confirmed that biologics are primarily associated with mild-to-moderate infections, with a low incidence of severe infections