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Amyloid (A ) has been implicated in both oxidative stress mechanisms and in neuronal apoptosis

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Eur Rev Med Pharmacol Sci 21:47114719 Tien L-T, Lee Y-J, Pang Y, Lu S, Lee JW, Tseng C-H, Bhatt AJ, Savich RD, Fan L-W (2017) Neuroprotective Effects of Intranasal IGF-1 against Neonatal Lipopolysaccharide-Induced Neurobehavioral Deficits and Neuronal Inflammation in the Substantia Nigra and Locus Coeruleus of Juvenile Rats