paracetamol glutathione depletion metabolism Too much paracetamol = dangerous
Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Drug toxicity and overdose Basicmedical Key A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N acetyl meta aminophenol (AMAP) Archives of Toxicology Springer Nature Link Association of antioxidant nutraceuticals and acetaminophen (paracetamol): Friend or foe? ScienceDirect Mind the Anion Gap: 5 Oxoproline Induced High Anion Gap Metabolic Acidosis in End Stage Renal Disease Cureus
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