glutathione to treat cancer Application of depletion in therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy Full article: Nanozyme-mediated glutathione depletion

Introduction Reactive oxygen species (ROS), once perceived as toxic by-products, were known to cause oxidative damage in cells (Mittler et al., 2 O 2 is an endogenous ROS species known to play a dual role in plants, where it is beneficial at low concentrations but lethal at higher levels (Petrov and Van Breusegem, 2 O 2 acts as signaling molecule inducing the signal transduction mechanism to produce various cellular responses

External metabolic stressors, such as excessive alcohol consumption and tobacco-smoking, increase the risk of conversion to symptomatic disease

Typically, under regular circumstances, GPx is the main enzyme responsible for breaking down most of the H 2 O 2 by transforming reduced GSH into GSSG

It blocks the renal tubular absorption of sodium and chloride ions

Neurotherapeutics 6, 436446