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4, 5 Among the growth factors involved in the proliferation step, hepatocyte growth factor (HGF), transforming growth factor alpha (TGF ) and epidermal growth factor (EGF) induce hepatocytes to override the mitogen restriction point located at 2/3 of G1 phase

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The deregulation mainly arises from the potentiated pro-angiogenic factors secretion and can also target immune cells' biological events, such as migration and activation