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10.3389/fnagi.2018.00160 144 YanH

Elsevier, Amsterdam, pp 219301 Martel JL, Kerndt CC, Doshi H, Franklin DS (2021) Vitamin B1 (thiamine)

By combining metformin and simvastatin, the transition of SREBP2 precursor to its mature form is inhibited, resulting in a downregulation of SREBP2 mature form, making it challenging to act as a transcription factor to alter GLUT1/6 levels