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In fact, if Glutaminase faces the intermembrane space, here, releases Glutamate then, a Glutamate transporter, not a Glutamine one, is required to allow entry of Glutamate in the TCA

Furthermore, a lot of trials are underpowered because of their short durations or small sample numbers, which restricts their statistical reliability and generalizability to larger populations (74)

Conclusion and future research directions The attractiveness and use of naturally occurring compounds including those derived from fruits, vegetables and herbs as potential chemopreventive and chemotherapeutic agents have become a fascinating strategy, and from the various studies reviewed here, it is evident that rooibos and/or its polyphenols hold great potential not only in the prevention but also in therapy of a wide variety of oxidative stress-induced conditions

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