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Calcitriol has been shown to enhance autophagic activity in podocytes and tubular cells by restoring LC3-II expression and autophagic flux, while concurrently reducing apoptosis through the modulation of Bcl-2 and Bax expression ( Klotho, an anti-aging factor predominantly expressed in the kidney, is downregulated in CKD and closely linked to vascular dysfunction

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Pregnancy and Lactation Available data from cases reported in the published literature and postmarketing surveillance with CYANOKIT use in pregnant women are insufficient to identify a drug-associated risk for major birth defects, miscarriage, or adverse maternal and fetal outcomes

Future research should address its pharmacokinetics, safety profile, and clinical potential

[Abstract] Adv Mater