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10.1016/j.pain.2013.02.023 36 HershmanD

Advanced glycation end-products (AGEs) play a significant role in impaired wound healing by promoting chronic inflammation and disrupting the normal healing process

Importantly, functional B12 deficiency can sometimes coexist with high total B12 levels, especially in kidney disease, and may require additional testing with methylmalonic acid (MMA) or holotranscobalamin if deficiency is suspected clinically

MMR removes the base opposite to the adduct, which may cause a new mismatch, starting the pathway again and leading to the so-called futile cycle, generating double stranded breaks

Disruption of adenosine-5-phosphosulfate kinase in Arabidopsis reduces levels of sulfated secondary metabolites