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Henrotin Y, Deberg M, Mathy-Hartert M, Deby-Dupont G

reported that the AMPK agonist metformin could ameliorate hyperglycemia-induced meibomian gland dysfunction (MGD), demonstrating that AMPK may be a therapeutic target for diabetes-induced MGD (92)

Furthermore, immunization with an mRNA vaccine led to loss of protection in the respiratory tract in mice lacking FcRIII

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Due to higher UGT1A3 expression in htgUGT1A -WT animals potentially leading to increased glucuronidation of FXR-inducing bile acids, unaffected UGT1A3 activity is suggested to reduce FXR activation leading to an impaired FXR-induced PPAR-mediated fatty acid oxidation