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Interestingly, when comparing the modulation of tg expression in both PTU-treated WT and nrf2a5 homozygous embryos, we observed a marked reduction in tg expression in nrf2a5 homozygous mutant embryos (Fig 2V)

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Zhang J, Zhang JX, Zhang QL

UNESCO, United Nations Educational, Scientific and Cultural Organization

Obstruction of GSH synthesis affects the lipid membrane repair ability of GPX4, increases the rate of toxic lipid free radical and ROS accumulation, and promotes lipid peroxidation, resulting in ferroptosis [1, 2]