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brown adipose tissue: 300 g)

4a,b) support a mechanism in which mitochondrial complex I inhibition promotes antioxidant gene expression and NADPH production, leading to TXNIP suppression and subsequent GLUT1 upregulation

Type V protein secretion pathway: the autotransporter story

This amplified cycle leads to persistent JNK activation and peroxynitrite formation in the face of depleted or inactivated antioxidant protection mechanisms, such as GSH, which normally reduces H 2 O 2 , O 2 .- and ONOO

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