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FIGURE 4 While spin traps and nitroxides may possess significant therapeutic potential, their clinical applications may be limited by poor bioavailability and targeting and inadequate BBB penetration (mainly due to low lipophilicity)

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Notably, confounding factors, including dietary habits, are often overlooked in most RCTs, but when patients are being enrolled in a study with antioxidant supplementation, baseline antioxidant intake and diet should be evaluated in both partners, male and female

Carcinogenesis 34 (7), 14421449

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