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The authors suggest that adequate vitamin B6 levels may avert psychological distress during emotional situations, such as grieving, by regulating serotonin levels.[47] Cardiovascular Support Elevated levels of homocysteine have been identified as an independent risk factor for coronary artery disease.[48] Independent of its place in the methylation cycle, evidence also suggests that homocysteine is in itself a toxic compound that can directly promote atherosclerosis, neuronal damage and mood disturbances.[49] Therefore, hyperhomocysteinaemia is not only a marker of reduced methylation status, but also a direct pathogenic agent

Kessler AT, Bhatt AA

J Hypertens 18:18331840 Moorthy K, Sharma D, Basir SF, Baquer NZ (2005) Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats

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ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway