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intramuscular route: count injections given Visit 3 (week 26) Anamnesis: record lifestyle habits and use of alcohol Symptoms: if pathological at the first visit, record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: if pathological at the first visit examine for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Request analyses to be performed one week before next visit: haemogram and serum vitamin B12 Questionnaire: EuroQoL-5D Assessment of adverse effects Therapeutic plan: patient in oral arm provision of medication

Starting Dose of 1,000 mcg Weekly The first dose of 1,000 mcg weekly is a common start

Your age, health, and lifestyle can change how often you need B12 injections

Usually, the reconstituted drug in the vial is used within 48 hours to 1 week

Non-modifiable factors you should know Age is the most significant unchangeable factor - most cases occur between ages 30-50