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10.3389/fnins.2010.00052 21 GargusJ

It has also been shown that Baicalin can improve TNBS-induced dysbiosis of the UC intestinal flora by reducing the ratio of Firmicutes to Bacteroidetes, increasing the level of butyric acid, and regulating the metabolism of SCFAs (Zhu et al., 2020b)

This imbalance in lipid metabolism creates a lipotoxic microenvironment, where reactive oxygen species (ROS) are excessively produced due to the oxidation of FFAs, a key factor in driving cellular stress