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The appearance of CT2 in cancers is shared with another plasma membrane transporter responsible for regulating the traffic of essential amino acids, that is LAT1 (SLC7A5

A., Webber, M

Phosphofructokinase-1 is the step exhibiting the highest flux-control coefficient in the pathway of glycolysis, thus representing the rate-limiting step (though this author advises against using the terminology rate-limiting step, as all steps in glycolysis and in any other pathway are rate-limiting, albeit to different extents)