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Dose Adjustments Renal Insufficiency (Kidney Problems): No specific dose adjustments are required, as excess B12 is naturally flushed out in the urine

329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes

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However, specific data on burning sensations as a distinct symptom are not separately quantified in the prescribing information

Scialabba C, Puleio R, Peddis D, Varvaro G, Calandra P, Cassata G, Cicero L, Licciardi M, Giammona G (2017) Folate targeted coated SPIONs as efficient tool for MRI