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However, spermatogonia loss was higher than Sertoli and Leydig cell loss after busulfan exposure (39) and because the status of spermatic germ cells depends on Leydig and Sertoli cells function, apoptosis of these supporting cells can also endanger vitality of spermatic germ cells (46)

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We anticipate that more efficacious intervention strategies that protect neural cells against METH-induced neurotoxic consequences may be implemented in the future