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Many of these products are required to be administered in high or repeated doses to achieve the desired therapeutic effect and also need to be administered in combination with high concentrations of DMSO

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Nat Rev Endocrinol 13(10):610622 Kujur A, Srivastava N, Kumar B, Jasrotia N, Arunpandian J, Ganeshan M (2021) Fetal congenital goiter in goat: a case report

Interestingly, treatment with insulin, hydrocortisone and ethanol, which induced only GCLC, increased the GSH synthesis capacity by 50 to 100% at the most (Lu et al., 1992b