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This upregulation aligns with previous studies showing that mutations in the OsPK1 and OsPK5 genes [43], which disrupt monosaccharide metabolism, result in slower germination and seedling growth

As an antioxidant, BH4, the enzymatic product of GCH1, effectively neutralizes ROS and reactive nitrogen species (187,188)

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10.3390/cells11162552 [DOI] [PMC free article] [PubMed] [Google Scholar] 123.Caltagirone C, Cisari C, Schievano C, Di Paola R, Cordaro M, Bruschetta G, et al

Reduced thalamic GSH and increased oxidative stress may affect the local neurochemical environment of the thalamus through several interconnected mechanisms