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There are multiple drugs producing clinically relevant weight loss 9 , including semaglutide (S)a long-acting glucagon-like peptide-1 (GLP-1) 10 analogue and cagrilintide (C)a long-acting amylin analogue 11

Emerging research and real-world experience suggest GLP-1 meds help reduce flares, pain, and inflammation in various inflammatory and autoimmune diseases, especially when obesity or insulin resistance is also present. What are the current barriers to getting GLP-1 medications (cost, coverage)

Inhibition of the growth of Caco-2 and MOLT 4 cancerous cell lines was observed in a dosage and time-reliant manner, respectively, with considerably high inhibition at 10,000 g/mL and at 120 min, respectively

Similarly, no significant changes in LINE-1 and Alu methylation among female nurses was observed, although several gene-specific hypomethylation effects to the estrogen receptor gene ESR1 (associated with heightened estrogen sensitivity), to the tumor suppressor genes TP53 and BRCA1 (indicating possible disruption in cell cycle regulation and DNA repair mechanisms) were reported

Although not all studies have found significant effects, risk estimates for the majority of studies are positive