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dispose in a sharps container [14]

It is surprising that the technique of LCMS characterizes the detection limit below 0.1 pg L 1 , where the LOD for the GCMS technique with derivatization is a value above 100 pg L 1 (Hottenroth et al

Data Availability Statement No data were generated in this manuscript.

Although no randomized trials exist, the uniformity of observational data has led GeneReviews and European neurometabolic taskforces to issue class I recommendations for immediate high-dose riboflavin upon molecular diagnosis (14)

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