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In previous studies, ROS levels were increased in patients with tendinopathy (Yoshida et al., 2020), and an in vivo study showed that tendinopathic changes in the patellar tendon are attributed to H 2 O 2 (Wunderli et al., 2020), activate several pathways, including the c-Jun N-terminal kinase (JNK) (Wang et al., 2007) and NF-B pathways ( We found that dexamethasone mitigated fluoroquinolone-induced oxidative stress primarily through the upregulation of GPX3, an antioxidant belonging to the glutathione peroxidase family

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[Google Scholar] Sharma A, Mishra M, Shukla A, Kumar R, Abdin M, Chowdhuri DK (2012)

86 The shunt should be attenuated as close as possible to the point where it enters the systemic circulation