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Experimental and theoretical studies determined the mechanism of antioxidant action

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In women, evidence suggests that the relationship among circulating concentrations of free 17 estradiol, free testosterone and sex hormone binding globulin may be more predictive of changes in carotid intimal thickening than concentrations of any of these hormones alone (Karim et al., 2008)

The manifestations of mitochondrial dysfunction are complex and diverse in SIC, mainly in the electron transport chain and oxidative phosphorylation abnormalities, mitochondrial structure abnormalities, oxidative and nitrite stress, mitochondrial calcium overload, mitochondrial autophagy dysregulation, and mitochondrial dynamics imbalance (3537)

Although CD8 + T cells sensitize target cancer cells to ferroptosis 225 , in syngeneic tumour models, it was found that ferroptosis-blocking antioxidant treatment improves responses to immunotherapy by preventing the immunosuppressive death of tumour-associated neutrophils 226