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Two mechanisms of reaction of these species with DNA and proteins are known: type I mechanism, involving one-electron transfer, and type II mechanism which can be divided into two subtypesmajor mechanism based on reaction with DNA via singlet oxygen, resulting in formation of 8-oxoguanine, and minor mechanism based on formation of a superoxide anion radical which undergoes disproportionation reaction, giving hydrogen peroxide and reactive oxygen species (IARC 2012)

In contrast, in infertile men, Se treatment (200 g Se per day for 3 months in the form of high-Se yeast) improved sperm motility (but not concentration), together with improved anti-oxidant status, total antioxidant capacity (TAC), and superoxide dismutase (SOD) activity (186)

Leukemic stem cells and therapy resistance in acute myeloid leukemia

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Moreover, evidence that the compromised white matter integrity of specific spinal pathways has been linked to clinical disability [69,70,71], and cortical reorganization [72] should be considered in relation to the pleiotropic beneficial effect of BPC 157 administration observed in distinctive brain areas and lesions [32,33,34,35,36,37,38,39,40]