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2 , CD004292 (2020)

11 The diagnostic evaluation of POTS starts with a focused history centering on symptom onset and progression, comorbid conditions, precipitating and exacerbating factors, and positional dependence

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152,153 Minority mitochondrial outer membrane permeabilization (miMOMP) normally occurs in senescent cells, enhances the secretion of mtDNA into the cytoplasm and stimulates the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway to promote SASP

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