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In normal prostate, vascular endothelial growth factor (VEGF) expression is restricted to stromal cells

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8.1 Nanoparticles affecting NK cells and T cells A variety of nanoparticles have been shown to be able to simultaneously regulate NK cells and T cells to improve anti-tumor immunity, such as the zinc ions released by the nanoclusters of zinc-sulfur@bovine serum albumin in the acidic tumor microenvironment by the self-assembly method can significantly enhance the signal of cyclic guanosine-adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) thereby promoting the infiltration of CD8 + T cells and the cross-presentation of NK cells at the tumor site, and improving the effectiveness of tumor immunotherapy (191)