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This systems-level approach is increasingly common in modern regenerative biology research

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Innovative strategies in combating intervertebral disc degeneration: pathological mechanisms and biomaterial advancements

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When an individual is faced with a stressor, the hypothalamus releases corticotropin-releasing hormone (CRH), which stimulates the anterior pituitary gland to secrete adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce cortisol, which plays a key role in the stress response [75,76]