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It is recommended to take one serving for every 60 kg of body weight one hour before training

doi:10.1097/MEG.0000000000001499

This step should be based on joint fluid biomarkers (such as COMP, CTX-II), and coordinated with physical therapy (strength training, low-frequency pulsed current stimulation, cold and heat therapy, etc.) and drugs (such as NSAIDs, intra-articular injections)