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2 Synthesis and metabolism of curcumin Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), is a naturally occurring polyphenolic compound that serves as the principal bioactive constituent extracted from the rhizomes of Curcuma longa , a perennial herbaceous plant belonging to the Zingiberaceae family ( 3 Curcumin inhibits the pro-inflammatory activation of immune cells in the central nervous system 3.1 Macrophages Curcumin exhibits significant immunomodulatory effects on macrophages, which are pivotal innate immune cells involved in inflammatory responses and tissue homeostasis