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Am J Transplant Off J Am Soc Transplantationand Am Soc Transplant Surgeons (2010) 10:269

Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, et al

Ann Hematol 80:S37, 2001

TGF-1 activates Smad2/3, PI3K/Akt, ERK1/2, GSK-3 and/or p38MAPK signalling to induce pulmonary fibrosis and EMT

We will discuss the life-sustaining importance of GSH, its relationship with oxidative stress, as well as its synthesis and catabolism, its biological functions and the paramount relevance of GSH in the immune system (especially the innate immune system), in reducing COVID-19 severity and mortality, and the antiviral capabilities of GSH to reduce SARS-CoV-2 infectivity and multiorgan failure secondary to a cytokine storm in COVID-19 disease