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However, NOX2-specific deletion or gp91ds-tat pharmacological inhibition of NOX2 activity effectively impairs ET-1 overexpression, which inhibits ERK1/2 transduction of microglia-mediated neuroinflammation, thereby rescuing glaucomatous RGC loss and ON axonal injury by attenuating iBRB injury and neurovascular unit (NVU) dysfunction (Fig

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100 l/mouse) or equal amount of vehicle was intraperitoneally injected with OVA/Alum after the evaluation of sneezing and nasal rubbing