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Antigen-specific B cell responses to SARS-CoV-2, the authors write, are predominantly mounted against regions within the Nucleocapsid (N) and Spike (S) protein antigens. They add that, The evaluation of serological memory in numerous studies has shown both disease severity-associated differences in circulating antigen-specific antibody titers, as well as waning of N and S protein-specific antibodies over time after both disease resolution and vaccination. Other studies of N- and S-specific memory B cells have shown the maintenance or an increase in these populations after either the resolution of infection or after vaccination with the BNT162b2 mRNA COVID-19 vaccine