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Clinical Evidence Human Trials: A randomized, placebo-controlled study in obese adults demonstrated that AOD-9604 significantly reduced abdominal and total body fat over several weeks of treatment, without serious side effects Animal Studies: Preclinical studies in mice and rats showed that AOD-9604: Stimulated lipolysis Inhibited lipogenesis (formation of new fat) Prevented weight gain despite high-fat diets This dual actionenhancing fat breakdown and inhibiting fat formationpositions AOD-9604 as a potent tool for combating obesity

10.1016/S2213-8587(23)00004-9 38 FerreiraG

Authored by Jacqueline Tourville, Managing Editor Ozempic and other GLP-1 medications can be effective for weight management

This globular fold consisting mostly of loops is held together by numerous hydrogen bonds and contains a conserved cysteinehistidine cluster, which could stabilize the fold by binding metal ions (Fig 7C)