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Role of histone deacetylase inhibitor in diabetic painful neuropathy

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ZDHHC20 palmitoylates EGFR on the C-terminal domain (C1025) to promote its ubiquitination-mediated lysosomal degradation, thus upregulating p85 binding and phosphatidylinositol 3-kinase (PI3K) signaling and inhibiting Grb2 binding and MAPK signaling

Unlike macrophages, smooth muscle cell death interferes mainly with plaque vulnerability by affecting the components of the fibrous cap on the surface of the plaque (Sampilvanjil et al., 2020)