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10.1016/j.actbio.2018.12.051 21 BrselerF.TietmannC.BommerC.DrechselT.Heinzel-GutenbrunnerM.JepsenS

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95 Although copper appears to be related to the hepatic inflammatory reaction, copper levels are typically less than 2000 g/g dry weight, the minimum amount of copper that is believed to cause hepatocellular injury in Bedlington Terriers and West Highland White Terriers.60, 61 A primary copper retention disorder has been proposed, 28 but the genes associated with Bedlington copper toxicity (COMMD1) and Wilson disease in humans (ATP7B) have been excluded

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However, long-chain fatty acids are incapable of permeating this barrier and gaining entry into the mitochondria for -oxidation