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At the end of each week, a pill count was performed to assess compliance

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By day 52, cumulative Dox exposure reached 30 mg/kg, at which point significant LV dilation and functional failure are known to occur, consistent with prior models [1]

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This distinction is critical: the preserved formula allows repeated doses to be drawn from the same multi-dose vial without risk of contamination, provided proper aseptic technique is maintained

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The 28-day use window applies only to refrigerated storage

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Jul 12 2023;11(7)doi:10.3390/biomedicines11071964

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