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Anemia: Overview and Types (e.g., sickle cell disease Sickle cell disease Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (HbS) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage

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The ER integrates nutrient sensing across cell types through regulation of calcium fluxes and lipid metabolic programs, coordinating cellular responses to metabolic fluctuations (113)

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