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An up-to-date finding demonstrated that -synuclein released from injured DNs triggers activation of NF-B and release of pro-inflammatory cytokines with further aggravation of DNs in a positive-loop fashion (Dolatshahi et al

This serves two purposes: it activates wound-healing pathways (Wnt/-catenin signalling, stem cell activation) that independently stimulate hair growth, and it creates micro-channels that deliver the three active compounds directly to the hair follicle bulge region where stem cells and dermal papilla cells reside

However, the molecular mechanism and clinical impact of histone lactylation in GC remain poorly understood

These effects typically resolve within days

For many ESG factors, the evidence base is still evolving