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Depending on the particular suite of initiating environmental and genetic factors, the trajectory of impaired mitochondrial biology maximally impacts subsets of mitotypes abundant in the hallmark neurodegenerative regions particular to AD, PD, ALS, or HD, which leads to a relatively pronounced failure of energy and metabolism in these regions

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Replenishing and maintaining glutathione levels through supplementation, they suggest, could therefore provide therapeutic benefit in Parkinsons disease patients