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& Jandeleit-Dahm, K

R., McCaddon, A., Ahmadi, K

Major Market Drivers & Challenges Drivers : Increasing prevalence of vitamin B12 deficiency (affecting ~1015% of adults globally, per NIH studies)

In this same pathway of sulfur amino acids, HCY can be metabolized producing glutathione (GSH) ( Figure 1 ) ( IL1B and CCL3 also play a central role in the pathophysiology of COVID-19 ( Figure 1 The hypothesis of this study is that, during the advanced phase of COVID-19, characterized by hyperinflammation (cytokine storm), supplemental vitamin B12 would increase the flow of the sulfur amino acid pathway, favoring the production of SAM and the antioxidant GSH

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