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The association of ROS with neuronal degeneration in PD is further substantiated by modeling the Parkinsonian phenotypes in animals through 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, 1,1-dimethyl-4,4-bipyridinium dichloride (paraquat), or 6-hydroxydopamine (6-OHDA), those are known of elevate the oxygen free-radicals in the cell 18

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doi: 10.3389/fnins.2016.00080 Received 17 December 2015 Accepted 18 February 2016 Published 09 March 2016 Volume 10 - 2016 Edited by Roberto Canitano, University Hospital of Siena, Italy Reviewed by Munis Dundar, Erciyes University, Turkey