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A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: preclinical activity and safety in nonhuman primates

The landmark 2017 mouse study The foundational research, published in The Journal of Investigative Dermatology by Lee et al., demonstrated several key findings

The company develops glutathione resin solutions supporting recombinant protein purification, molecular biology applications, and advanced therapeutic research programs

This suggests, at least, a potential in the maintenance of the remission state and the prevention of disease flares in IBD patients

In schizophrenia, immune activation upregulates pro-inflammatory cytokines (e.g., IFN-, IL-1, TNF-), which activate indoleamine 2,3-dioxygenase (IDO) via both IFN- receptor (IFN-R)-dependent and independent pathways (e.g., synergistic action of TLR4, IL-1R, TNF-R) (215)