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or s.e.m., as indicated

Rats were housed in temperature-controlled rooms with a 12 hour light/dark cycle

Copper itself is a comparatively weak skin sensitizer a 2014 review (PMID 25098945) reported positive copper patch-test reactions in roughly 3.8% of tested subjects so contact allergy is possible but uncommon

The standard mouse-to-human dose conversion uses body-surface-area scaling (FDA guidance: divide mouse mg/kg by 12.3 for adult human equivalent)