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A further step toward understanding synaptic plasticity in inhibitory neurons would require knowledge of forms and mechanisms of plasticity that can be induced by natural patterns of activity, typical for each specific type of inhibitory neurons

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Notably, HIF-2, another key HIF family member also regulated by hypoxia and sharing some target genes, may exhibit distinct roles from HIF-1 in ROS regulation, sometimes even promoting ROS generation under specific conditions, highlighting the nuanced complexity of this family in ROS homeostasis [136]

J Syst Integr Neurosci