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Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis

These results validated that ZZW-115 worked efficiently in blocking the nuclear translocation of NUPR1 in our culture model and that inhibition of NUPR1 nuclear translocation induces cell death in phBECs, indicating an important protective role in bronchial epithelial cells

FBPase and SBPase catalyze the hydrolysis of FBP and SBP to Fru6P and Sed7P, respectively

Our findings open avenues to identify cancer subtypes that hyperprogress in response to ICT by hijacking myeloid-affiliated pathways and thus allows for the development of effective combination therapies by targeting this mechanism of hyperprogression, and also support the emerging strategy of combining epigenetic modulators with ICT to prevent tumor-promoting epigenetic processes in cancers that are resistant to ICT 50 and possibly other therapies

[DOI] [PMC free article] [PubMed] [Google Scholar] 143.Ge Y., Chen J