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Furthermore, I148M oe macrophages had an impaired mitochondrial electron transport chain (ETC) system as reflected by significantly reduced cofactors, FAD and NAD metabolites, as well as genes linked to the ETC complexes, MT-ND1, MT-SHDA, MT-CYTB, MT-CO1, MT-CO2, and ATP6 in both MASH patients and macrophages carrying the PNPLA3 I148M variants, accompanied by reduced mitochondrial ROS production (-15%)

J Dement Alzheimers Dis

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After harvesting is done, the spears grow into ferns, which produce red berries and the food and nutrients necessary for a healthy and productive crop the next season

10.1126/science.1092385